TEMPO氧化醇到羟基酮

0.04–1 M solution of the alcohol in DCM, containing 0.09–0.2 equiv., typically 0.1 equiv. of TEMPO and 1.1–5 equiv., typically 1.1 equiv. of PhI(OAc) 2(BAIB), is stirred at room temperature till most of the starting alcohol is consumed. Then, some DCM may be optionally added in order to facilitate subsequent washings. The reaction mixture is washed with an aqueous Na 2S 2O 3 solution. Optionally, the organic phase can be washed with aqueous NaHCO 3and brine. Finally, the organic solution is dried (Na 2SO 4) and concentrated, giving a residue that may need further purification.

此前提下中间体不要求无水，中间体时间2-12h。

中间体机理

中间体实例

【 J. Org. Chem. 1996, 61 , 7452】

【 Org. Synth. 2006, 83 , 18】

参考文献

一、common oxidation reagents, Yue Xu, Sundia Meditech

二、化学空间：TEMPO的氧中间体

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